Acetaminophen adducts and methods of use thereof

The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts.

ABSTRACT

The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts.

CLAIMS

1. A method for measuring the amount of acetaminophen-protein adduct in a biological sample, the method comprising: a) obtaining a biological sample from a subject having or suspected of having acetaminophen toxicity; and b) measuring the total amount of acetaminophen-protein adduct in the sample, wherein the acetaminophen-protein adducts are detected using high performance liquid chromatography (HPLC) or an immunoassay comprising an antibody with specific for NAPQI bound to a protein through a 3-(cystein-S-yl) APAP (3-Cys-A)-protein linkage.

PATENT INFORMATION


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