The present disclosure provides compositions and methods for selectively killing cancer cells, wherein the composition comprises a compound of Formula (I). The selective killing of cancer cells occurs with an improved potency and safety profile compared to similar compounds. In particular, the compositions and methods of the invention show reduced platelet toxicity and retained or improved toxicity in cancer cells.
1. A compound comprising Formula (I): wherein A is an E3 ubiquitin ligase binding unit which binds to an E3 ubiquitin ligase and n is an integer from 0 to 3.