Compositions and Methods for Improved Organ Transplant Outcomes: Tissue Protection During Transport and Storage

Protection against injury to organs or tissues during pre-transplant storage and transport


An antibody composition to treat drug use, drug addiction, and effects of drug use


• Improved outcomes for transplanted organs
• Better preservation of organs will mean greater availability of organs


Approximately seventy thousand organ transplants are performed each year, and the number continues to grow. Approximately 60% of those transplants involve kidney transplants. There is a growing list of people in need of organ transplants, and better methods are needed to preserve available organs. Current research has demonstrated that increased oxidant and free radical production contributes to organ damage prior to and following organ transplantation. Cold preservation and ischemia contribute to the deterioration of the organs and tissues during the period of organ isolation while testing for a suitable recipient is performed. This damage limits the number of organs available for transplantation and can lead to limited function of a transplanted organ.


The present invention provides a composition for the cold storage of organs which reduces oxidation effects of cold storage and reduces the oxidative damage to an organ or tissue. The composition comprises a biochemical substrate that is targeted to the mitochondria and functions as an electron transporter to stabilize various reactive oxygen species that are one source of tissue and organ damage.
The composition is the property of a third party with which the University is currently collaborating. The methods of use for this are the proprietary information of the University. The composition includes a mitochondrial specific antioxidant
moiety related to the lipophilic electron transporter called coenzyme Q10 that is covalently attached to a triphenylphosphonium cation. This invention could make available much greater numbers of human organs for transplantation, reduce the number of discarded human organs prior to transplantation and improve the outcomes for organs that have been transplanted.


Solution tested in animal model


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