ABSTRACT
Disclosed herein are RNA methyltransf erase inhibitors and methods of using and making the same. The inhibitors may be used in a method for the treatment of a subject in need of a treatment for a cancer by administering an effective amount of the RNA methyltransferase inhibitor and an effective amount of a DNA damaging agent to the subject.
CLAIMS
1.An RNA methyltransferase inhibitor of formula or a pharmaceutically acceptable salt thereof, wherein Ri and R2 are independently selected from hydrogen; an unsubstituted or substituted, unbranched or branched, saturated or unsaturated, acyclic or cyclic Ci – Ce alkyl; hydroxide; an unsubstituted or substituted, unbranched or branched, saturated or unsaturated, acyclic or cyclic Ci – Ce alkoxy; an unsubstituted or substituted, unbranched or branched, saturated or unsaturated, acyclic or cyclic Ci – Ce amino; an unsubstituted or substituted aryl; or an unsubstituted or substituted heteroaryl; and wherein Ar1and Ar2are independently selected from an unsubstituted or substituted aryl or an unsubstituted or substituted heteroaryl.