ABSTRACT
The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.
CLAIMS
1. A method for inhibiting growth of a blood cancer cell, wherein the cancer cell is a leukemic cell, the method comprising contacting the cancer cell with an effective amount of composition comprising a compound of Formula (Id), or a pharmaceutically acceptable salt thereof, wherein the composition is effective to inhibit growth of the cancer cell, wherein the compound comprises Formula (Id): wherein: R is proline; and R3 is selected from hydrogen, CH3, CH2OH, CH2NH2, CH2Cl, CH2Br, CH2l or CH2F; R6 is hydrogen; and R8 is selected from hydrogen CH3, CH2OH, CH2NH2, CH2Cl, CH2Br, CH2l or CH2F.