ABSTRACT
A device and methods for the non-invasive manipulation and detection of target objects such as cells, pathogens, microparticles, and nanoparticles in vivo using an external magnetic field are described. In one aspect, a device and method for capturing and detecting intrinsically magnetic target objects or target objects labeled with at least one magnetic particle within the area of interest using an in vivo flow cytometer are described.
CLAIMS
1. A device for the manipulation and detection of a magnetic target object within a moving biofluid of a living organism, comprising:an in vivo flow cytometer for detecting the magnetic target object within an area of interest, wherein the in vivo flow cytometer is an in vivo photoacoustic flow cytometer comprising: at least one laser; at least one optical module; and at least one ultrasound transducer; and at least one magnet for producing a magnetic field that manipulates the magnetic target object within the area of interest.