ABSTRACT
The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.
CLAIMS
1. A process for producing a compound comprising Formula (I):wherein: R1, R5 and R6 are hydrogen and R2, R3, and R4 are independently chosen from hydrogen, methoxy, and hydroxyl, with the proviso that at least two of R2, R3, and R4 are methoxy; Ar is an aryl or substituted aryl group; the processes comprises contacting a compound of Formula (II) or Formula (III): wherein R1, R2, R3, R4, R5 and R6 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, alkylalkylamino, amidine, amino, carboxyl, cyano, ester, halogen, hydroxyl, and nitro, and Ar is an aryl or substituted aryl group, with an azide in the presence of a proton donor or proton acceptor.