Hetero-substituted cyclic lactone analogues and uses thereof

The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.

ABSTRACT

The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.

CLAIMS

1. A method for inhibiting growth of a cancer cell derived from a blood cancer, the method comprising contacting the cancer cell with an effective amount of a composition comprising a compound of Formula (II) or a pharmaceutically acceptable salt thereof: wherein: R1, R2 and R3 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl, wherein one or more of R1, R2 and R3 comprise a substituted hydrocarbyl comprising an atom selected from the group consisting of fluorine, oxygen, nitrogen, chlorine, bromine, and iodine; R4 and R5 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl;  is a single or double bond; and  is a SL ring structure, minus the lactone ring, from the class of guaianolides.

PATENT INFORMATION


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