ABSTRACT
The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
CLAIMS
1. A method for inhibiting growth of a cancer cell derived from a blood cancer, the method comprising contacting the cancer cell with an effective amount of a composition comprising a compound of Formula (II) or a pharmaceutically acceptable salt thereof: wherein: R1, R2 and R3 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl, wherein one or more of R1, R2 and R3 comprise a substituted hydrocarbyl comprising an atom selected from the group consisting of fluorine, oxygen, nitrogen, chlorine, bromine, and iodine; R4 and R5 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl; is a single or double bond; and is a SL ring structure, minus the lactone ring, from the class of guaianolides.