Provided herein are compounds, comprising Formula (I) or Formula (II), and their pharmaceutically acceptable salts. Also provided are pharmaceutical compositions comprising a pharmaceutically acceptable excipient and at least one compound of Formula (I) and (II), singly or in combination with other pharmaceutically active ingredients, such as anti-inflammatory agents or anticancer agents. These compounds and pharmaceutical compositions are useful for treating inflammation or an inflammation related disorder in a subject via administration to the subject. These compounds and pharmaceutical compositions are also useful for inhibiting COX-2, for treating cancer, for reducing the size of a neoplasm, and for inhibiting tubulin polymerization in a cell.
1. A compound comprising Formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 is chosen from hydrogen, halogen, hydrocarbyl, and substituted hydrocarbyl; R2 is chosen from hydrocarbyl and substituted hydrocarbyl; X1 is chosen from hydrocarbyl, substituted hydrocarbyl, nitrogen, oxygen, and sulfur; X2 is chosen from hydrocarbyl, substituted hydrocarbyl, nitrogen, oxygen, and sulfur; and n is an integer from 0 to 10.