Inhibitors of oxidized low-density lipoprotein receptor 1 and methods of use thereof

Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described.

ABSTRACT

Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described.

CLAIMS

1. A compound, the compound comprising Formula (I):wherein: X is selected from the group consisting of oxygen, sulfur, sulfoxide, sulfone, and nitrogen; Y1 and Y2 are independently selected from the group consisting of carbon and nitrogen R1, R2, R3, R4, R6, R7, R8, R9 and R19 are each independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, hydroxyl, aldehyde, haloformyl, hydroperoxyl, halogen, amino, phosphor, sulfhydryl, sulfino, sulfo, C1-C5 alkyl, cyano, and halogen, with the proviso that when Y1 is nitrogen, R4 is absent and/or when Y2 is nitrogen R3 is absent; R5 independently in each occurrence is selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, hydroxyl, aldehyde, haloformyl, hydroperoxyl, halogen, amino, phosphor, sulfhydryl, sulfino, sulfo, C1-C6 alkyl, cyano, and halogen; and n is an integer from 1 to 10.

PATENT INFORMATION


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