ABSTRACT
The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).
CLAIMS
1. A method for treating cancer, comprising administering a therapeutically effective amount of a compound comprising Formula (I), or a pharmaceutically acceptable salt thereof, to a patient in need thereof, according to the following formula: wherein: Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N; Y is independently selected from the group consisting of O, NR, N, heterocycle, hydrocarbyl and substituted hydrocarbyl; X is selected from the group consisting of (CH2)n, C(O), —(CH2)n—W—C(O)—, —C(O)—W—C(O)—, —C(O)NH—W—NHC(O)—, —C(O)O—W—OC(O)—, carbocycle, heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl; R is selected from the group consisting of H, alkyl, hydrocarbyl and substituted hydrocarbyl; W is selected from the group consisting of O, S, NH, N-alkyl, heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl; and n is an integer from 0-10.