A method of coating a surface with nanoparticles for biological analysis of cells that includes the steps of cleaning the surface with an oxidizing acid, treating the surface with an organosilane, coating the surface with nanoparticles, and then growing cells on the surface coated with the nanoparticles. The surface may be a glass surface, a silica-based surface, a plastic-based surface or a polymer-based surface. The nanoparticles may be gold-based nanomaterials.
1. A method of coating a surface with a nanoparticle for biological analysis of a cell, comprising the steps of: a. cleaning said surface with an oxidizing acid; b. treating said surface with an organosilane; c. coating said surface with said nanoparticle; and d. growing said cell on said surface coated with said nanoparticle.