The present invention is drawn to methods of repairing lytic bone lesions and tumor growth in an individual. In this regard, the present invention discloses use of a Wnt ligand either alone or in combination with anti-Wnt signaling antagonist therapy. The individuals who might benefit from such method may include but are not limited to the ones with multiple myeloma, osteoporosis, post-menopausal osteoporosis, fractures, metastatic breast cancer or metastatic prostate cancer.
1. A method of repairing or treating lytic bone lesions in an individual with multiple myeloma, comprising: expressing Wnt-3a in said individual; and blocking the activity of the human homologue of Dickkopf-1 (DKK1), wherein the activity of the human homologue of DKK1 is blocked prior to, concurrent with or subsequent to said expression of the Wnt-3a ligand.