ABSTRACT
The present inventors have developed antigen-binding reagents and antigen-binding conjugates that recognize a cancer-specific glycan (carbohydrate) modification on the human Periostin protein. Various in vitro and in vivo diagnostic and/or therapeutic methods using these compositions are also disclosed herein specifically for treating cancers that have amplification of the Mgat3 gene.
CLAIMS
1. An antigen-binding reagent comprising at least threee of the following complementarity-determining regions (CDRs): CDR H1.