Photosensitizer conjugated nanoparticles for radiotherapy enhancement

Among the various aspects of the present disclosure is the provision of compositions and methods for targeted treatment of cancers or neoplasms. In particular, the present disclosure is directed to a photodynamic system comprising a nanoparticle conjugated to a photosensitizer that can be activated by an excitation source such as ionizing radiation or other forms of electromagnetic energy.

ABSTRACT

Among the various aspects of the present disclosure is the provision of compositions and methods for targeted treatment of cancers or neoplasms. In particular, the present disclosure is directed to a photodynamic system comprising a nanoparticle conjugated to a photosensitizer that can be activated by an excitation source such as ionizing radiation or other forms of electromagnetic energy.

CLAIMS

1. A nanoparticle composition, comprising: a scintillation nanoparticle having a coating layer and a photosensitizer conjugated to the coating layer, wherein the scintillation nanoparticle emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic radiation having a second wavelength and wherein the photosensitizer absorbs electromagnetic radiation of said first wavelength.

PATENT INFORMATION


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