Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise γ-tocotrienol (GT3) and δ-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
1. A method of treating a subject in need of a radioprotectant or for treatment of radiation exposure, the method comprising administering an effective amount of a tocotrienol composition comprising δ-tocotrienol and γ-tocotrienol in a ratio of between 2:1 and 10:1.