Preparation and use of a composition for prevention and mitigation of the effects of radiation

Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise γ-tocotrienol (GT3) and δ-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.

ABSTRACT

Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise γ-tocotrienol (GT3) and δ-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.

CLAIMS

1. A method of treating a subject in need of a radioprotectant or for treatment of radiation exposure, the method comprising administering an effective amount of a tocotrienol composition comprising δ-tocotrienol and γ-tocotrienol in a ratio of between 2:1 and 10:1.

PATENT INFORMATION


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