Methods and compositions for expanding long-term hematopoietic stem cell populations

The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.

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Compositions and Methods for Generating Reversion Free, Attenuated and/or Replication Incompetent Vaccine Vectors

This invention provides methods for generating reversion free, attenuated and/or replication incompetent vaccine vectors and their use in vaccine compositions and vaccination.

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