Author: Bioventures Team

Device and method for in vivo photoacoustic diagnosis and photothermal purging of infected blood

A method of non-invasively detecting and purging bacterial cells using a modified photoacoustic in vivo flow cytometer device is described herein. In particular, a method of detecting bacterial cells by analyzing photoacoustic pulses emitted in response to laser pulses from a pulsed laser source and/or selectively destroying the detected bacterial cells using a non-linear photothermal response induced by a high-energy laser pulse is described herein.

September 13, 2022

Small molecule parg inhibitors and methods of use thereof

“The present disclosure provides methods of inhibiting PARG in cancer cells, including methods comprising administering a PARG inhibitor that modulates position Tyr795 in PARG. Also provided herein are methods of treating and/or preventing cancer comprising administering a PARG inhibitor. In some embodiments, the PARG inhibitors are of the formula: wherein the variables are defined herein.

September 13, 2022

Technology

Sound-based spirometer system

A sound-based spirometer system including a spirometer and an electronic device having a microphone. The spirometer includes an air inlet and an air outlet. The spirometer generates a sound as an unknown amount of air passes from the air inlet to the air outlet. The sound is recordable by the microphone, and the electronic device processes the sound to determine the volume and flow rate of the unknown amount of air.

September 13, 2022

Cellulose based Anti-viral Anti-microbial spray coating

A cellulose based anti-viral/anti-microbial coating.

September 13, 2022

Nek2 proteolysis targeting chimeras for use in malignant disease

This invention describes a small molecule proteolysis targeting chimera (PROTAC) strategy to degrade the NEK2 (Never in Mitosis Related Kinase 2) protein and methods of use thereof. The NEK2 PROTAC consists of three, key regions: a NEK2 ligand to bind the NEK2 protein, a linker region to link the NEK2 ligand to a ligase ligand, and the ligase ligand.

September 13, 2022

Cells for the production of viruses and methods of using the same

The present disclosure provides compositions and methods for increasing the production of virus in vitro. Modified cells which are modified to eliminate or reduce as compared to a control cell the activity or expression of a Sterile a motif-domain containing protein 9 (SAMD9) polypeptide are provided. Methods of using these cells are also provided.

September 13, 2022

Cst6, cells expressing cst6 and methods of use

The present invention provides methods of treating bone loss or cancer using CST6. In these methods, CST6 may be provided as a recombinant CST6 protein, a polynucleotide construct comprising CST6, or an immune cell expressing CST6 protein.

September 13, 2022

Compositions and methods for the treatment and diagnosis of cancer

Disclosed herein are RNA methyltransf erase inhibitors and methods of using and making the same. The inhibitors may be used in a method for the treatment of a subject in need of a treatment for a cancer by administering an effective amount of the RNA methyltransferase inhibitor and an effective amount of a DNA damaging agent to the subject.

September 13, 2022

Use of amino acid supplementation for improved muscle protein synthesis

The present invention encompasses an amino acid composition for stimulating muscle protein synthesis. Further, the present disclosure relates generally to the use of an anabolic amino acid composition for the stimulation of muscle protein synthesis. In particular, disclosed are compositions and methods of using the same for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal, especially an adult mammal. Also provided are kits comprising a composition for the stimulation of muscle protein synthesis and, in certain embodiments, instructions for administration.

September 13, 2022

Device and method for in vivo detection of clots within circulatory vessels

A device and method of using the device to detect the presence and composition of clots and other target objects in a circulatory vessel of a living subject is described. In particular, devices and methods of detecting the presence and composition of clots and other target objects in a circulatory vessel of a living subject using in vivo photoacoustic flow cytometry techniques is described.

September 13, 2022