The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I), Formula (II), and Formula (V) are provided.
The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).
The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.
You had come up with an idea for an invention? Here’s what you can do to make it a reality
Prior and competing art are fundamental to find out if your invention is patentable. Here is why!
Support to manage children’s behaviors & promote social-emotional development.
Automated, therapeutic device that heats and extends fingers that are curled due to hypertonia from cerebral palsy, stroke, multiple sclerosis, spasticity or other cause
Mechanical device that attaches an auscultation device to a smart device such as a smartphone.
This device analyses venous pressure to estimate anesthetic depth
Endotracheal tube cuff with integrated sensors to measure the pressure between the tube and the trachea.
